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butabarbital will decrease the extent or impact of nifedipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Importance Unfamiliar.butabarbital will reduce the level or outcome of sufentanil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Importance Not known.butabarbital will lower the level or effect of levoketoc